It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. Rams (-7.5)? All of the Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now. Seahawks (-3)? Is there value in any of the larger NFL betting lines like Bears vs. ![]() ![]() Which side should you back in tight games like Chargers vs. With a limited preseason, bettors have tough calls to make in the 15 games that remain this week, six of which have NFL Vegas spreads of a field goal or less. 49ers (-8.5) is the only exception in the latest Week 1 NFL spreads. The latest Week 1 NFL odds from Caesars Sportsbook list all but one Sunday game with a spread within one score. The Week 1 NFL schedule has arrived and oddsmakers are expecting plenty of tight games.
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